Risk prediction algorithms have evolved since Framingham to account for key risk factors and social determinants of health.

Revolutionary publications pave the way for polygenic risk scores and targeted therapy developments like PCSK9i and APOCIII.

• 1959

  Build and Blood Pressure Studies demonstrated increase in mortality associated with incremental increase in systolic and diastolic blood pressures.
  
• 1967

  Veterans Administration Cooperative Studies show evidence for the beneficial impact of lowering blood pressure with antihypertensive agents.
• 1970s

  NHLBI Hypertension Task Force formed to improve blood pressure control and treatment in the US.
  
• 2001

  Framingham Heart Study observes increments in systolic or diastolic blood pressure associated with increases in mortality.